Using instrumental variables to address bias from unobserved confounders

2 May 2019 - Randomised clinical trials are considered the most reliable source of evidence for the effects of medical interventions, ...

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The importance of predefined rules and pre-specified statistical analyses: do not abandon significance

4 April 2019 - For decades, statisticians and clinicians have debated the meaning of statistical and clinical significance.  ...

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Patient experience data and bias — what ratings don’t tell us

28 February 2018 - Although patient-experience data are important to U.S. health care organisations, the best way to interpret them remains ...

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Using the E value to assess the potential effect of unmeasured confounding in observational studies

24 January 2019 - Randomised trials serve as the standard for comparative studies of treatment effects.  ...

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Random-effects meta-analysis: summarising evidence with caveats

22 January 2019 - Questions involving medical therapies are often studied more than once. For example, numerous clinical trials have been ...

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Challenges of non-intention-to-treat analyses

15 January 2019 - Over the past 5 decades, the randomised clinical trial has become the gold standard for evaluation ...

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Establishing the effectiveness of procedural interventions: the limited role of randomised trials

18 December 2018 - Procedural interventions comprise a large and growing component of medical care. Patients, physicians, health care organisations, and ...

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Bayesian hierarchical models

11 December 2018 - Treatment effects will differ from one study to another evaluating similar therapies, both because of random variation ...

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Choice of control group in randomised trials of cancer medicine: are we testing trivialities?

31 August 2018 - Several trials in cancer medicine over the past 5 years share two common features: first, they were ...

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Pfizer calls for FDA guidance to address false and misleading biosimilar advertisements

28 August 2018 - Taking issue with Amgen, Genentech and other reference product sponsors’ dissemination of misleading information on biosimilars, ...

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Case-control studies: using “real world” evidence to assess association

23 August 2018 - Associations between patient characteristics or treatments received and clinical outcomes are often first described using observational data, ...

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Bias, operational bias, and generalisability in Phase II/III trials

27 June 2018 - Adaptive clinical trial designs improve the efficiency of the drug development process by allowing treatment decisions to ...

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EU Ombudsman confirms EMA’s correct handling of declared interests

24 November 2017 - Latest decision concludes no maladministration at EMA. ...

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Mendelian randomisation

21 November 2017 - Mendelian randomisation uses genetic variants to determine whether an observational association between a risk factor and an ...

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The value of using registries to evaluate randomised clinical trial study populations

5 June 2017 - Randomised clinical trials are considered the gold standard of medical research and influence clinical practice, but they ...

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