Biased Outcome reporting Guidelines for Underwhelming Studies (BOGUS) statement and checklist

10 December 2021 - A light hearted article to end the year. Merry Christmas to all our readers. We will ...

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Can we trust strong recommendations based on low quality evidence?

25 November 2021 - A necessary requirement for development of trustworthy guidelines is to respect the relation between the quality (certainty) ...

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Patient groups fail to declare financial interests during NICE assessments

16 January 2019 - Patients’ groups involved in assessing treatments for the NHS often fail to disclose their financial interests, ...

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Challenges and methodologies in using progression free survival as a surrogate for overall survival in oncology

11 July 2018 - A primary outcome in oncology trials is overall survival. However, to estimate overall survival accurately requires ...

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Drugs watchdog NICE attacks pharmaceutical industry in pricing dispute

25 September 2017 - Industry expert’s evidence is not independent, NICE argues. ...

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Managing conflicts of interest – making good decisions

24 July 2017 - NICE is seeking views on a new conflicts of interest policy to ensure its committees’ decisions ...

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Tackling submission and publication bias

17 July 2017 - Evoniuk and colleagues analysed whether submission and publication bias are based on study outcome. ...

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Confounding by indication in clinical research

1 November 2016 - In the assessment of the effect of a treatment or potential risk factor—termed an exposure—on a patient ...

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