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Posted by Michael Wonder on 13 Apr 2023

How ‘surrogate outcomes’ influence long-term health outcomes

13 April 2023 - NICE working with international organisations to develop guidance. ...

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Posted by Michael Wonder on 22 Feb 2021

Clinical relevance of patient-reported outcomes: new threshold proves to be practical

18 February 2021 - Current examples show that the 15% threshold newly set by IQWiG for the recognition of responder analyses ...

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Posted by Michael Wonder on 11 Sep 2020

Surrogate outcomes in health technology assessment: an international review of methodological guidelines

11 September 2020 - In the drive towards faster patient access to treatments, health technology assessment agencies are increasingly faced with ...

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Posted by Michael Wonder on 11 Jul 2018

Challenges and methodologies in using progression free survival as a surrogate for overall survival in oncology

11 July 2018 - A primary outcome in oncology trials is overall survival. However, to estimate overall survival accurately requires ...

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Posted by Michael Wonder on 22 Mar 2017

The role of imperfect surrogate endpoint information in drug approval and reimbursement decisions

22 March 2017 - Weakly correlated surrogates encourage payers and regulators to impose more stringent evidence thresholds. ...

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