Zolbetuximab in combination with chemotherapy for the first-line treatment of adults with claudin-18.2 positive, HER2 negative unresectable advanced gastric or gastro-oesophageal junction adenocarcinoma (final guidance)

12 March 2025 - NICE has published final evidence-based recommendations on the use of zolbetuximab (Vyloy) in combination with chemotherapy ...

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Natalizumab for the treatment of patients with highly active relapsing–remitting multiple sclerosis after disease-modifying therapy

12 March 2025 - The Department of Health and Social Care has asked NICE to produce guidance on the use ...

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Vertex announces UK MHRA approval of Alyftrek (deutivacaftor/tezacaftor/vanzacaftor), a once daily next in class CFTR modulator for the treatment of cystic fibrosis

7 March 2025 - In head to head clinical trials, deutivacaftor/tezacaftor/vanzacaftor was non-inferior on ppFEV1 and further decreased sweat chloride ...

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Lazertinib approved for use in combination with amivantamab for the treatment of adults with non-small cell lung cancer

6 March 2025 - The MHRA has today approved lazertinib (Lazcluze) for adults with non-small cell lung cancer that has spread ...

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Amivantamab in combination with pemetrexed disodium heptahydrate and carboplatin for the treatment of patients with advanced EGFR exon 20 insertion mutation positive non-small-cell lung cancer

6 March 2025 - The Department of Health and Social Care has asked NICE to produce guidance on the use ...

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Second consultation launched on NHS funding for Alzheimer's treatments

6 March 2025 - Cost and evidence gaps remain barriers to approving funding in the NHS for donanemab and lecanemab. ...

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Cemiplimab in combination with platinum-based chemotherapy for the treatment of patients with advanced non-small-cell lung cancer

5 March 2025 - The Department of Health and Social Care has asked the NICE to produce guidance on the ...

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Idebenone for the treatment of patients 12 years of age and older with visual impairment in Leber’s hereditary optic neuropathy (updated draft guidance)

5 March 2025 - NICE has produced additional draft guidance on the use of idebenone in the NHS in England. ...

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Sparsentan for the treatment of patients with primary IgA nephropathy

4 March 2025 - The Department of Health and Social Care has asked NICE to produce guidance on the use ...

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mRESVIA RSV vaccine approved to protect patients aged 60 and over

28 February 2025 - A study found that around 4 months after vaccination, people who received the respiratory syncytial virus vaccine had ...

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Exagamglogene autotemcel for the treatment of patients with severe sickle cell disease

26 February 2025 - NICE has published final evidence-based recommendations on the use of exagamglogene autotemcel (Casgevy) for the treatment ...

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Osimertinib mesylate for the adjuvant treatment of patients with EGFR mutation positive non-small-cell lung cancer after complete tumour resection (final guidance)

26 February 2025 - NICE has published final evidence-based recommendations on the use of osimertinib mesylate (Tagrisso) for the adjuvant ...

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Green light for groundbreaking personalised cancer therapy that reprogrammes immune system

20 February 2025 - Final guidance published today recommends lisocabtagene maraleucel (Breyanzi; Bristol Myers Squibb) as an option for treating ...

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Use of surrogate endpoints in health technology assessment: a review of selected NICE technology appraisals in oncology

19 February 2025 - Surrogate endpoints, used to substitute for and predict final clinical outcomes, are increasingly being used to support ...

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Selpercatinib for the treatment of patients with advanced RET fusion positive non-small-cell lung cancer

19 February 2025 - NICE has published final evidence-based recommendations on the use of selpercatinib (Retsevmo) for the treatment of ...

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