Blog
RSS FeedPosted by Michael Wonder on 16 Sep 2024
The sense and sensibility of sensitivity analyses
14 September 2024 - Clinicians and public health officials routinely make evidence-based decisions that affect patient and population level health. ...
Posted by Michael Wonder on 09 Apr 2024
Using effect scores to characterise heterogeneity of treatment effects
9 April 2024 - It is common for treatments to yield different outcomes in different patients. If patient characteristics that predict ...
Posted by Michael Wonder on 28 Sep 2023
Where medical statistics meets artificial intelligence
28 September 2023 - Challenges at the interface of medical statistics and AI are population inference versus prediction, generalisability, reproducibility and ...
Posted by Michael Wonder on 20 Jun 2023
Evidence of lack of treatment efficacy derived from statistically non-significant results of randomised clinical trials
20 June 2023 - Many randomised clinical trials yield statistically non-significant results. Such results are difficult to interpret within the dominant ...
Posted by Michael Wonder on 20 Feb 2023
Medicare annual statistics – rolling 12 months (July 2009 to December 2022)
20 February 2023 - This document presents rolling 12 month Medicare statistics by three variables ...
Posted by Michael Wonder on 08 Feb 2023
Stakeholders want more clarity on FDA's statistical approach to assessing bioequivalence
7 February 2023 - Commenters on the US FDA draft guidance outlining principles for in vivo or in vitro bioequivalence ...
Posted by Michael Wonder on 04 Dec 2022
Statistical approaches to establishing bioequivalence
2 December 2022 - Requirements for submitting bioavailability and bioequivalence data in investigational new drugs, new drug applications, abbreviated new drug ...
Posted by Michael Wonder on 31 Aug 2022
Pharmaceutical Benefits Scheme supplied medications
30 August 2022 - Key findings about health and population characteristics from the National Health Survey (NHS) and the Pharmaceutical Benefits ...
Posted by Michael Wonder on 04 Aug 2022
Regression models for ordinal outcomes
4 August 2022 - Ordinal logistic regression models are tailored for the analysis of ordinal outcomes. ...
Posted by Michael Wonder on 02 Aug 2022
Patient reported outcome measures in clinical research
2 August 2022 - Health conditions may cause patients to feel ill and have impaired functioning in their daily lives. Thus, ...
Posted by Michael Wonder on 07 Jul 2022
Testing for differences in survival when treatment effects are persistent, decaying, or delayed
7 July 2022 - A statistical test for the presence of treatment effects on survival will be based on a null ...
Posted by Michael Wonder on 23 Mar 2022
Instrumental variables and heterogeneous treatment effects
22 March 2022 - A randomised clinical trial can be used to estimate the average treatment effect for a population. ...
Posted by Michael Wonder on 15 Mar 2022
Collider bias
14 March 2022 - Bias is a systematic, non-random error in the estimation of a treatment effect or the effect of ...
Posted by Michael Wonder on 02 Mar 2022
Assessing unexpected circumstances that lead to modifications in clinical trial design, conduct, or analysis application of the CONSERVE Reporting Guideline
1 March 2022 - In the COVID-19 Dexamethasone (CoDEX) randomised clinical trial, which studied a sample of critically ill patients with ...
Posted by Michael Wonder on 14 Dec 2021
Heterogeneity of treatment effect; estimating how the effects of interventions vary across individuals
14 December 2021 - ...