Biostatistics: a fundamental discipline at the core of modern health data science

28 October 2019 - The value of our health and medical research investment is at risk unless we foster the discipline ...

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Using instrumental variables to address bias from unobserved confounders

2 May 2019 - Randomised clinical trials are considered the most reliable source of evidence for the effects of medical interventions, ...

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The importance of predefined rules and pre-specified statistical analyses: do not abandon significance

4 April 2019 - For decades, statisticians and clinicians have debated the meaning of statistical and clinical significance.  ...

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The stepped wedge cluster randomised trial: what it is and when it should be used

1 April 2019 - The basic premise of a stepped wedge cluster randomised trial is that all clusters start in the ...

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Marginal effects—quantifying the effect of changes in risk factors in logistic regression models

8 March 2019 - Marginal effects can be used to express how the predicted probability of a binary outcome changes ...

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Number needed to treat: conveying the likelihood of a therapeutic effect

7 February 2019 - Effectively communicating clinical trial results to patients and clinicians is a requirement for appropriate application in ...

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Using the E value to assess the potential effect of unmeasured confounding in observational studies

24 January 2019 - Randomised trials serve as the standard for comparative studies of treatment effects.  ...

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Random-effects meta-analysis: summarising evidence with caveats

22 January 2019 - Questions involving medical therapies are often studied more than once. For example, numerous clinical trials have been ...

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Challenges of non-intention-to-treat analyses

15 January 2019 - Over the past 5 decades, the randomised clinical trial has become the gold standard for evaluation ...

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FDA approves 59 novel drugs in 2018

8 January 2019 - The past year proved to be a big one for the U.S. FDA and the approval ...

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Can the record breaking number of FDA new drug approvals continue?

9 January 2019 - The late 1990s had been thought of as a golden-age for the drug industry.  ...

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Bayesian hierarchical models

11 December 2018 - Treatment effects will differ from one study to another evaluating similar therapies, both because of random variation ...

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Multiplicity considerations in clinical trials

31 May 2018 - Making multiple comparisons increases the likelihood that a chance association could be interpreted as causal.  ...

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Understanding statistical principles in linear and logistic regression

7 May 2018 - A previous article in this series assessed the association between two variables. Here, we introduce the concept ...

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Guided by the research design: choosing the right statistical test

5 March 2018 - Choosing the right statistical test or model can be baffling for researchers, and if it is not ...

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