Blog
RSS FeedPosted by Michael Wonder on 02 Jul 2020
Regression discontinuity design
2 July 2020 - The method is used to study the outcomes related to an abrupt change when it is not ...
Posted by Michael Wonder on 14 Mar 2020
Why test for proportional hazards?
13 March 2020 - The Cox proportional hazards model, introduced in 1972, has become the default approach for survival analysis in ...
Posted by Michael Wonder on 18 Nov 2019
Biostatistics: a fundamental discipline at the core of modern health data science
28 October 2019 - The value of our health and medical research investment is at risk unless we foster the discipline ...
Posted by Michael Wonder on 03 May 2019
Using instrumental variables to address bias from unobserved confounders
2 May 2019 - Randomised clinical trials are considered the most reliable source of evidence for the effects of medical interventions, ...
Posted by Michael Wonder on 04 Apr 2019
The importance of predefined rules and pre-specified statistical analyses: do not abandon significance
4 April 2019 - For decades, statisticians and clinicians have debated the meaning of statistical and clinical significance. ...
Posted by Michael Wonder on 01 Apr 2019
The stepped wedge cluster randomised trial: what it is and when it should be used
1 April 2019 - The basic premise of a stepped wedge cluster randomised trial is that all clusters start in the ...
Posted by Michael Wonder on 09 Mar 2019
Marginal effects—quantifying the effect of changes in risk factors in logistic regression models
8 March 2019 - Marginal effects can be used to express how the predicted probability of a binary outcome changes ...
Posted by Michael Wonder on 08 Feb 2019
Number needed to treat: conveying the likelihood of a therapeutic effect
7 February 2019 - Effectively communicating clinical trial results to patients and clinicians is a requirement for appropriate application in ...
Posted by Michael Wonder on 25 Jan 2019
Using the E value to assess the potential effect of unmeasured confounding in observational studies
24 January 2019 - Randomised trials serve as the standard for comparative studies of treatment effects. ...
Posted by Michael Wonder on 23 Jan 2019
Random-effects meta-analysis: summarising evidence with caveats
22 January 2019 - Questions involving medical therapies are often studied more than once. For example, numerous clinical trials have been ...
Posted by Michael Wonder on 16 Jan 2019
Challenges of non-intention-to-treat analyses
15 January 2019 - Over the past 5 decades, the randomised clinical trial has become the gold standard for evaluation ...
Posted by Michael Wonder on 10 Jan 2019
FDA approves 59 novel drugs in 2018
8 January 2019 - The past year proved to be a big one for the U.S. FDA and the approval ...
Posted by Michael Wonder on 09 Jan 2019
Can the record breaking number of FDA new drug approvals continue?
9 January 2019 - The late 1990s had been thought of as a golden-age for the drug industry. ...
Posted by Michael Wonder on 12 Dec 2018
Bayesian hierarchical models
11 December 2018 - Treatment effects will differ from one study to another evaluating similar therapies, both because of random variation ...
Posted by Michael Wonder on 30 May 2018
Multiplicity considerations in clinical trials
31 May 2018 - Making multiple comparisons increases the likelihood that a chance association could be interpreted as causal. ...