Blog
RSS FeedPosted by Michael Wonder on 09 Mar 2019
Marginal effects—quantifying the effect of changes in risk factors in logistic regression models
8 March 2019 - Marginal effects can be used to express how the predicted probability of a binary outcome changes ...
Posted by Michael Wonder on 08 Feb 2019
Number needed to treat: conveying the likelihood of a therapeutic effect
7 February 2019 - Effectively communicating clinical trial results to patients and clinicians is a requirement for appropriate application in ...
Posted by Michael Wonder on 25 Jan 2019
Using the E value to assess the potential effect of unmeasured confounding in observational studies
24 January 2019 - Randomised trials serve as the standard for comparative studies of treatment effects. ...
Posted by Michael Wonder on 23 Jan 2019
Random-effects meta-analysis: summarising evidence with caveats
22 January 2019 - Questions involving medical therapies are often studied more than once. For example, numerous clinical trials have been ...
Posted by Michael Wonder on 16 Jan 2019
Challenges of non-intention-to-treat analyses
15 January 2019 - Over the past 5 decades, the randomised clinical trial has become the gold standard for evaluation ...
Posted by Michael Wonder on 10 Jan 2019
FDA approves 59 novel drugs in 2018
8 January 2019 - The past year proved to be a big one for the U.S. FDA and the approval ...
Posted by Michael Wonder on 09 Jan 2019
Can the record breaking number of FDA new drug approvals continue?
9 January 2019 - The late 1990s had been thought of as a golden-age for the drug industry. ...
Posted by Michael Wonder on 12 Dec 2018
Bayesian hierarchical models
11 December 2018 - Treatment effects will differ from one study to another evaluating similar therapies, both because of random variation ...
Posted by Michael Wonder on 30 May 2018
Multiplicity considerations in clinical trials
31 May 2018 - Making multiple comparisons increases the likelihood that a chance association could be interpreted as causal. ...
Posted by Michael Wonder on 07 May 2018
Understanding statistical principles in linear and logistic regression
7 May 2018 - A previous article in this series assessed the association between two variables. Here, we introduce the concept ...
Posted by Michael Wonder on 05 Mar 2018
Guided by the research design: choosing the right statistical test
5 March 2018 - Choosing the right statistical test or model can be baffling for researchers, and if it is not ...
Posted by Michael Wonder on 05 Feb 2018
Standard deviation and standard error: interpretation, usage and reporting
5 February 2018 - Standard deviations and standard errors are reported routinely in statistical analyses, but the distinction between them is ...
Posted by Michael Wonder on 14 Jan 2018
Distributions and what to do when they are non-normal
15 January 2018 - Medical researchers often want to find out how medically relevant outcomes are related to other factors. ...
Posted by Michael Wonder on 19 Dec 2017
Guidelines for statistical analysis plans
19 December 2017 - The emergence of the randomised clinical trial as the gold standard for the evaluation of new clinical ...