Basket trials: review of current practice and innovations for future trials

J Clin Oncol

10 May 2022 - Basket trials, one type of master protocol, emerged as a tool for evaluating biomarker-targeted therapies among multiple tumour histologies. 

Conventionally conducted within the phase II setting and designed to estimate high and durable objective responses, basket trials pose challenges to statistical design and interpretation of results. 

This article reviews basket trials implemented in oncology studies and discusses issues related to their statistical design and analysis.

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Michael Wonder

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Michael Wonder