Since September 2014, the fixed-dose combination of dolutegravir/abacavir/lamivudine (trade name Triumeq) has been approved for human immunodeficiency virus (HIV) infected adults and adolescents above 12 years of age. The Institute for Quality and Efficiency in Health Care (IQWiG), which had already assessed a dossier on dolutegravir in spring 2014, now examined in another dossier assessment whether the drug combination also offers an added benefit over the appropriate comparator therapy. 

According to the findings, there is an indication that adults who have not been treated for their HIV infection have considerable added benefit from treatment with the new fixed-dose combination. However, an added benefit versus the appropriate comparator therapy is not proven for adults with antiretroviral pretreatment and for adolescents with and without pretreatment, because suitable study data are lacking.

For more details, go to: https://www.iqwig.de/en/press/press-releases/press-releases/dolutegravir/abacavir/lamivudine-considerable-added-benefit-for-treatment-naive-adults-with-hiv.6512.html