5 July 2016 - The second article in the series describes the use of evidence to decision frameworks for clinical recommendations and how they can help clinicians and patients who use those recommendations.

Clinicians regularly face situations with two or more alternative actions. Each alternative often has different advantages and disadvantages, including differences in effectiveness, adverse effects, costs and other factors (criteria). To make these choices, clinicians rely on recommendations from clinical practice guidelines, other recommendations (such as from colleagues or experts) or implicit rules for decision making, such as based on their personal experience or what others do. To ensure trustworthiness, clinical practice guidelines are made by groups of people (guideline panels) with relevant skills, perspectives, and knowledge; they are informed by the best available evidence; and they are systematically developed.

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