Posted by Michael Wonder on 23 Aug 2018
NICE publishes final guidance for dinutuximab
22 August 2018 - Dinutuximab is used to treat children with brain cancer.
Dinutuximab beta is recommended as an option for treating high-risk neuroblastoma in people aged 12 months and over whose disease has at least partially responded to induction chemotherapy, followed by myeloablative therapy and stem cell transplant, only if:
- they have not already had anti-GD2 immunotherapy and
- the company provides dinutuximab beta according to the commercial arrangement.
Dinutuximab beta does not meet NICE's criteria for a life-extending treatment at the end of life. Also, the range of cost-effectiveness estimates presented is higher than what NICE usually considers a cost-effective use of NHS resources. But taking into account the uncaptured health-related benefits, the rarity and severity of the disease and the potential lifetime benefit for children with neuroblastoma, dinutuximab beta can be recommended for high-risk neuroblastoma.
