If a person needs to take two anti-diabetic drugs, canagliflozin is recommended as a possible treatment for people with type 2 diabetes when taken with metformin hydrochloride, only if the person:

• Cannot take a sulfonylurea or
• Is at significant risk of hypoglycaemia or its consequences

If a person needs to take three anti-diabetic drugs, canagliflozin is recommended as a possible treatment when taken with either metformin hydrochloride and a sulfonylurea, or metformin hydrochloride and a thiazolidinedione.

Canagliflozin is also recommended as a possible treatment when taken with insulin, with or without other anti-diabetic drugs.

For more details, go to: http://guidance.nice.org.uk/TA315