The stepped-wedge clinical trial

JAMA

13 February 2018 - Evaluation by rolling deployment.

Cluster randomised trials are studies in which groups of individuals, for example those associated with specific clinics, families, or geographical areas, are randomised between an experimental intervention and a control. A stepped-wedge design is a type of cluster design in which the clusters are randomised to the order in which they receive the experimental regimen. 

All clusters begin the study with the control intervention, and by the end of the trial (assuming no unexpected and unacceptable safety issues arise), all clusters are receiving the experimental regimen.

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Michael Wonder

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Michael Wonder