12 September 2025 - Real world evidence is increasingly used to assess and make regulatory decisions on health technologies. However, its application in health care payer decision-making is less well-known.

The objectives of this study were to (i) review the recent literature on how real world evidence has been used by health care payers, (ii) highlight barriers that limit the use of real world evidence in payer decision making, and (iii) explore how real world evidence has been used in various funding arrangements between payers and manufacturers.

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