A systematic review on the appropriate discounting rates for the economic evaluation of gene therapies: whether a specific approach is justified to tackle the challenges

International Journal of Technology Assessment in Health Care

10 May 2024 - Discounting the cost and effect for health intervention is a controversial topic over the last two decades. In particular, the cost effectiveness of gene therapies is especially sensitive to the discount rate because of the substantial delay between the upfront cost incurred and long-lasting clinical benefits received. 

This study aims to investigate the influence of employing alternative discount rates on the incremental cost effectiveness ratio  of gene therapies.

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Michael Wonder

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Michael Wonder