Adjustment for baseline characteristics in randomised clinical trials


17 November 2022 - The purpose of randomisation in clinical trials is to ensure that there are no systematic differences between treatment groups with respect to measured and unmeasured baseline characteristics that could influence the outcome of interest.

In a randomised clinical trial without selection or information bias, an unadjusted analysis (ie, an analysis that does not take baseline characteristics into account) will provide unbiased estimates of treatment effects.

Read JAMA Guide to Statistics and Methods

Michael Wonder

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Michael Wonder

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US , Clinical trial , Bias