Posted by Michael Wonder on 21 Nov 2022
Adjustment for baseline characteristics in randomised clinical trials
17 November 2022 - The purpose of randomisation in clinical trials is to ensure that there are no systematic differences between treatment groups with respect to measured and unmeasured baseline characteristics that could influence the outcome of interest.
In a randomised clinical trial without selection or information bias, an unadjusted analysis (ie, an analysis that does not take baseline characteristics into account) will provide unbiased estimates of treatment effects.
