Industry sponsorship bias in cost effectiveness analysis: registry based analysis

22 June 2022 - The Tufts Cost-Effectiveness Analysis Registry was used to identify all CEAs published in Medline between 1976 and ...

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Instrumental variables and heterogeneous treatment effects

22 March 2022 - A randomised clinical trial can be used to estimate the average treatment effect for a population.  ...

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Collider bias

14 March 2022 - Bias is a systematic, non-random error in the estimation of a treatment effect or the effect of ...

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Biased Outcome reporting Guidelines for Underwhelming Studies (BOGUS) statement and checklist

10 December 2021 - A light hearted article to end the year. Merry Christmas to all our readers. We will ...

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Can we trust strong recommendations based on low quality evidence?

25 November 2021 - A necessary requirement for development of trustworthy guidelines is to respect the relation between the quality (certainty) ...

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Strengthening the reporting of observational studies in epidemiology using Mendelian randomisation: the STROBE-MR Statement

26 October 2021 - An international expert committee, informed by the methodological framework for guideline development of the Enhancing the Quality ...

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Generating high quality evidence from registry based studies

26 October 2021 - EMA has published guidance to provide key methods and good regulatory practices to pharmaceutical organisations on ...

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Interpreting the results of intention to treat, per protocol and as treated analyses of clinical trials

 3 August 2021 - Non-adherence in a randomised clinical trial occurs when study participants do not follow the randomly assigned treatment ...

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Health care funding decisions and real world benefits: reducing bias by matching untreated patients

14 June 2021 - Governments and health insurers often make funding decisions based on health gains from randomised controlled trials.  ...

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Immortal time bias in observational studies

16 February 2021 - Observational studies are commonly used to evaluate the association between a risk factor or “exposure” and the ...

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From publication bias to lost in information

11 December 2020 - In BMJ Evidence-Based Medicine, IQWiG researchers call for a central, public and worldwide portal for clinical ...

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Characteristics and strength of evidence of COVID-19 studies registered on ClinicalTrials.gov

27 July 2020 - The coronavirus disease 2019 (COVID-19) pandemic has led to a massive activation of clinical research.  ...

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Weighing the benefits and risks of proliferating observational treatment assessments: observational cacophony, randomised harmony

31 July 2020 - Amid the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, substantial effort is being directed toward ...

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Regression discontinuity design

2 July 2020 - The method is used to study the outcomes related to an abrupt change when it is not ...

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The pandemic claims new victims: prestigious medical journals

14 June 2020 - Two major study retractions in one month have left researchers wondering if the peer review process is ...

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