Regression discontinuity design

2 July 2020 - The method is used to study the outcomes related to an abrupt change when it is not ...

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The pandemic claims new victims: prestigious medical journals

14 June 2020 - Two major study retractions in one month have left researchers wondering if the peer review process is ...

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Overlap weighting: a propensity score method that mimics attributes of a randomised clinical trial

5 May 2020 - Evidence obtained from clinical practice settings that compares alternative treatments is an important source of information about ...

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Finding effective treatments for COVID-19: scientific integrity and public confidence in a time of crisis

16 April 2020 - Everyone wants new treatments and vaccines to address the devastation of coronavirus disease 2019 (COVID-19). ...

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Why test for proportional hazards?

13 March 2020 - The Cox proportional hazards model, introduced in 1972, has become the default approach for survival analysis in ...

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EMA adopts EU Ombudsman recommendations to avoid bias concerns over drug approvals

26 November 2019 - Seeking to end another flap about transparency, the European Medicines Agency has agreed to recommendations made ...

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Placebos and blinding in randomised controlled cancer clinical trials for drug and biological products: guidance for industry

28 August 2019 - This guidance provides recommendations to industry about the use of placebos and blinding in randomised controlled clinical ...

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Statement on data accuracy issues with recently approved gene therapy

6 August 2019 - As a public health agency, we believe that it is critical to facilitate the development of ...

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Surrogate endpoints in randomised controlled trials: a reality check

27 July 2019 - At the 24th Congress of the European Hematology Association in June, 2019, the results of the BELLINI ...

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European Medicines Agency is advised to take steps to avoid bias concerns over approvals

22 July 2019 - Following a two-year inquiry, the European Ombudsman has recommended the European Medicines Agency take several steps ...

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Using instrumental variables to address bias from unobserved confounders

2 May 2019 - Randomised clinical trials are considered the most reliable source of evidence for the effects of medical interventions, ...

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The importance of predefined rules and pre-specified statistical analyses: do not abandon significance

4 April 2019 - For decades, statisticians and clinicians have debated the meaning of statistical and clinical significance.  ...

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Patient experience data and bias — what ratings don’t tell us

28 February 2018 - Although patient-experience data are important to U.S. health care organisations, the best way to interpret them remains ...

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Using the E value to assess the potential effect of unmeasured confounding in observational studies

24 January 2019 - Randomised trials serve as the standard for comparative studies of treatment effects.  ...

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Random-effects meta-analysis: summarising evidence with caveats

22 January 2019 - Questions involving medical therapies are often studied more than once. For example, numerous clinical trials have been ...

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