Can we trust strong recommendations based on low quality evidence?


25 November 2021 - A necessary requirement for development of trustworthy guidelines is to respect the relation between the quality (certainty) of evidence and strength of recommendations. 

Strong recommendations are justified when they are based on high quality evidence, because such recommendations are considered more accurate.

On the other hand, uncertainty in benefits and harms (that is, low quality evidence) generally leads to weaker recommendations.

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Michael Wonder

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Michael Wonder