Posted by Michael Wonder on 04 Aug 2021
Interpreting the results of intention to treat, per protocol and as treated analyses of clinical trials
3 August 2021 - Non-adherence in a randomised clinical trial occurs when study participants do not follow the randomly assigned treatment protocol.
Reasons for non-adherence may include the study participant not taking trial medications, crossing over to the other intervention being studied, or accessing treatment outside of the trial.
Non-adherence also may occur when the clinician is unable to complete the assigned therapy (eg, a surgical procedure) as intended.
