Cluster randomised trials

4 March 2019 - Cluster randomised trials randomise groups of individuals rather than individuals themselves to interventions.  ...

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Treatment effects in multi-centre randomised clinical trials

1 March 2019 - It is common for treatments to be evaluated in clinical trials that involve many sites or centres, ...

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Under representation of elderly in clinical trials: an analysis of the initial approval documents in the FDA database

25 February 2019 - A cross‐sectional, structured review of publicly available initial approval documents of FDA approved drugs was performed.  ...

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Modernising clinical trials for patients with cancer

23 January 2019 - Clinical trials involve evaluating and validating new therapies in humans and represent the fundamental means of making ...

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Random-effects meta-analysis: summarising evidence with caveats

22 January 2019 - Questions involving medical therapies are often studied more than once. For example, numerous clinical trials have been ...

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Lilly reports results of Phase 3 soft tissue sarcoma study of Lartruvo

18 January 2019 - Lartruvo in combination with doxorubicin previously showed an overall survival benefit in soft tissue sarcoma in a ...

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FDA is urged to mandate disclosure of clinical trial summaries as pilot program stalls

16 January 2019 - One year after the FDA launched a voluntary pilot program to release clinical study reports, which ...

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Sweet smell of success for patients taking the sugar pill

15 January 2019 - A placebo is anything that seems to offer a real medical treatment, but doesn’t. It could ...

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Challenges of non-intention-to-treat analyses

15 January 2019 - Over the past 5 decades, the randomised clinical trial has become the gold standard for evaluation ...

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Establishing the effectiveness of procedural interventions: the limited role of randomised trials

18 December 2018 - Procedural interventions comprise a large and growing component of medical care. Patients, physicians, health care organisations, and ...

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Metastasis-free survival in prostate cancer: faster drug approvals, better drugs?

12 December 2018 - On 13 February 2018, the US FDA granted marketing authorisation to apalutamide for treatment of non-metastatic castration-resistant ...

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Australia's first telehealth cancer drug trial

3 December 2018 - A partnership between north Queensland hospitals is bringing potentially life-saving cancer drug trials to rural patients. ...

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The evolution of adaptiveness: balancing speed and evidence

29 November 2018 - 'Adaptive' approaches to bringing drugs to market have been widely discussed in recent years.  ...

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Lung cancer survivor wants PHARMAC to fund drugs she received in trial

22 October 2018 - Lung cancer patient Marjolein Baas takes the drug ceritinib, one of six lung cancer treatment drugs the ...

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Congratulations. Your study went nowhere.

23 September 2018 - Researchers should embrace negative results instead of accentuating the positive, which is one of several biases that ...

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