Federal Government to announce $50 million custom cancer drug trial

17 July 2018 - Almost 600 Queenslanders will have their cancer’s DNA tested to identify the drugs that will keep ...

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Bias, operational bias, and generalisability in Phase II/III trials

27 June 2018 - Adaptive clinical trial designs improve the efficiency of the drug development process by allowing treatment decisions to ...

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Finding cancer patients is the pharma industry’s unlikely challenge

20 June 2018 - Doctors will need to test 100 patients to find one candidate. ...

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Effect of cross-over in oncology clinical trials on evidence levels in early benefit assessment in Germany

13 June 2018 - In oncology clinical trials, cross-over is used frequently but may lead to uncertainties regarding treatment effects. ...

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Clinical trial design and dissemination: comprehensive analysis of clinicaltrials.gov and PubMed data since 2005

6 June 2018 - Well conducted clinical trials are widely regarded as the best source of evidence on the efficacy and ...

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Clinical trial participants’ views of the risks and benefits of data sharing

7 June 2018 - Sharing of participant-level clinical trial data has potential benefits, but concerns about potential harms to research participants ...

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Multiplicity considerations in clinical trials

31 May 2018 - Making multiple comparisons increases the likelihood that a chance association could be interpreted as causal.  ...

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Are big clinical trials relevant? Researchers disagree

29 May 2018 - Amid health care tailored to an individual’s DNA, do massive clinical trials that take years and involve ...

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Key design considerations for adaptive clinical trials: a primer for clinicians

8 March 2018 - This article reviews important considerations for researchers who are designing adaptive clinical trials.  ...

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The stepped-wedge clinical trial

13 February 2018 - Evaluation by rolling deployment. ...

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Cancer research funding has an inherent bias that often excludes rare cancers, expert says

3 February 2018 - The biggest investor in cancer research in Australia needs to address an "inherent bias" in how ...

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Standard deviation and standard error: interpretation, usage and reporting

5 February 2018 - Standard deviations and standard errors are reported routinely in statistical analyses, but the distinction between them is ...

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EU proposes joint studies to speed acceptance of new medicine

31 January 2018 - The European Commission proposed on Wednesday joint clinical assessments to determine whether approved new drugs and ...

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Characteristics of interim publications of randomised clinical trials and comparison with final publications

23 January 2018 - Publication of interim results of randomised trials can be consequential, potentially undermining trial integrity by unblinding or ...

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FDA Commissioner on new steps FDA is taking to enhance transparency of clinical trial information to support innovation and scientific inquiry related to new drugs

16 January 2018 - Scientific progress and new drug innovation don’t take place in a vacuum.  ...

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